Endocrine Abstracts

Generously supported by IPSEN)-->It is known that acromegaly is associated with increased risk of benign and malignant tumours. Previous studies show the prevalence of nodular thyroid disease in 40–70% of patients with acromegaly, and a 5–7% prevalence of thyroid cancer in these patients, which is higher compared to the general population.Latvian Cancer Register data show an incidence of thyroid cance...

Metformin is a biguanide class agent widely used as a first-line treatment for type 2 diabetes, however the detailed mode of action and exact pharmacodynamics has not been clarified. Moreover there is no studies in humans displaying the effect of metformin on DNA methylation. We therefore performed a clinical study involving twelve healthy nondiabetic individuals who were subjected to the 1 week of metformin (2×850 mg/day) treatment. Peripheral blood for DNA isolation was...

Pituitary adenomas (PA) are benign tumors that develop in pituitary gland. Hormone secreting PA can cause overproduction of pituitary hormones leading to different systemic endocrine disorders (acromegaly, Cushing’s disease and others). Non-secreting PA can promote headaches (stretching of the dural sheath) and visual field defects (chiasma compression). We managed to obtain resected tumor samples from the patient having non-secreting PA, first tumor was resected in 2010,...

Pituitary neuroendocrine tumors (PitNETs) are non-metastatic neoplasms of the pituitary that may overproduce hormones leading to systemic disorders or tumor mass effects causing headache, vertigo, or visual impairment. The overall estimated clinical prevalence of PitNETs is 1 in 400 to 1 in 1000 people. Although the pathogenesis of PitNETs has been extensively studied the molecular factors underlying tumorigenesis, remission, and therapy response of PitNETs are still unclear. ...

Introduction: Pituitary adenomas (PA) are tumours of the anterior pituitary. Despite the benign nature these neoplasms cause increased mortality and morbidity. Clinically relevant PAs affect around 0.1% of population during their lifetime. Currently, there is no human PA cell culture models. Tissue cultures derived from PA surgery materials depending on harvesting conditions can form free floating aggregates called pituispheres (PS) or adherent mesenchymal stromal cells (MSC)....